Billy Price first attracted national attention during his three-year association with guitarist Roy Buchanan. Price is the vocalist on two of Buchanan's LPs, That's What I'm Here For and Live Stock. Since then, with the Keystone Rhythm Band, the Billy Price Band, and solo projects, Billy Price has recorded and released a total of 20 albums, CDs, and DVDs.

Price’s album This Time for Real, with the late Chicago soul singer Otis Clay, received a 2016 Blues Music Award in the category of best soul blues album. He was nominated seven times for BMAs between 2019 and 2024 and won the 2024 Bluebird Reviews Lifetime Career Award in the U.K.

The Billy Price Band, based in Billy’s hometown of Pittsburgh, Pa., consists of Dave Dodd (drums), Tom Valentine (bass), Lenny Smith (guitar), Jim Britton (keyboards), Eric Spaulding (sax), and Joe Herndon (trumpet).

His latest recording is Person of Interest, on the Little Village label.